SCARB2 and Cognitive impairment: The common clinical features observed in the AMRF patients harboring SCARB2 pathogenic variants include myoclonus (n = 29), ataxia (n = 28), tonic clonic seizures (n = 24), dysarthria (n = 20), tremor (n = 19) and renal impairment (n = 18), whereas the uncommon features of those involve PNP (n = 5), hearing loss (n = 2), and cognitive impairment (n = 4).