IL6 and Fever: For this purpose, it has been associated with cHIS with 6 separate criteria: Fever, macrophage activation (hyperferritinaemia), hematological dysfunction (neutrophil to lymphocyte ratio), hepatic injury (elevated LDH or AST), coagulopathy (elevated D-dimer), and cytokinaemia (elevated CRP, interleukin-6 or triglycerides).