Comparing the backgrounds, in surgery period 2007–2013 (vs. 2000–2006), there was less jaundice (25% vs 40%, p = 0.031), lower CEA (2.4 vs 3.8 ng/mL, p = 0.006), more gallbladder bed resection (5% vs. 17%, p = 0.008 [less ≥ 3 segment hepatectomy 31% vs. 41%, p = 0.17), less bleeding (740 vs 1016 mL, p < 0.001), less AJCC T4 (15% vs 28%, p = 0.035), less peritoneal metastasis (4% vs 12%, p = 0.065), and less residual cancer (22% vs 40%, p = 0.008). The gene discussed is CEACAM5; the disease is cancer.