A total of 1210 GC patients from 6 studies reported the relationship between lymph node metastasis (N1-3 and N0) and the expression of PROX1 (OR: 2.161, 95% CI 0.808–5.779, P = 0.125) (Fig. 4 and Additional file 1: Table S1). This evidence concerns the gene PROX1 and gastric cancer.