Moreover, baseline CRP levels can be correlated with the continuation of anti-TNFα agents in patients with rheumatoid arthritis [46] and with a colectomy-free rate in patients with ulcerative colitis in the active phase [47]; for continued long-term maintenance therapy with anti-TNFα, we may need to maintain a high trough level of anti-TNFα agents by employing corticosteroids or immunosuppressive agents in patients with high CRP levels at baseline, higher dosages of anti-TNFα agents, or shorter dosing intervals in patients with escalated activity during anti-TNFα therapy. This evidence concerns the gene TNF and rheumatoid arthritis.