The crucial role of the PI3K/AKT/mTOR (PAM) pathway in cell survival, proliferation, growth, apoptosis, and glycogen metabolism and its frequent activation or over expression in many types of human cancers, such as breast, ovarian, prostatic, lung, gastric, pancreatic cancers, and B-cell lymphomas has put it in the line of promising druggable targets in the war against cancer.3–5. The gene discussed is MTOR; the disease is cancer.