For example, while data contained within the In Silico Transcriptomics Online database (https://ist.medisapiens.com) (Kilpinen et al., 2008) show tremendous variation in SKP1 (ENSG00000113558) mRNA expression in both normal and tumor tissues (see (Thompson et al., 2021)), they also reveal that some cancers exhibit increases (head and neck; chronic lymphocytic leukemia; liver) or decreases (breast; ovarian; cervical; colorectal) in SKP1 expression relative to the corresponding normal tissues. The gene discussed is SKP1; the disease is B-cell chronic lymphocytic leukemia.