Interestingly, and in agreement with SKP1 being a putative tumor suppressor gene, the mutational load is equally distributed (i.e., diffuse) across the entire coding sequence (Figure 2B), rather than a focal mutational load that is typical of an oncogene (Liu et al., 2011; Vogelstein et al., 2013; Sato et al., 2015). The gene discussed is SKP1; the disease is neoplasm.