SKP1 and cancer: Indeed, strong positive correlations exist between copy number changes and mRNA expression for all 12 cancer types investigated (Figure 3), and while the copy number alterations detailed above suggest SKP1 may encode both oncogene-like or tumor suppressor-like functions, these seemingly opposing activities are not specific to SKP1 and have been reported for other genes including TP53 (Lane, 1984; Jenkins et al., 1985; Finlay et al., 1989), USP22 (Jeusset and McManus, 2017), and RAD54B (McAndrew and McManus, 2017).