SKP1 and cancer: In support of reduced SKP1 expression and/or function harboring a potential pathogenic role in oncogenesis, in silico analyses of The Cancer Genome Atlas (TCGA) pan-cancer atlas patient data available through cBioPortal (Cerami et al., 2012; Gao et al., 2013) reveal that SKP1 is somatically altered in 12 common solid tumor cancer types (Figure 2) (Hoadley et al., 2018).