A second study by Lepage and others (Lepage et al., 2021), assessed the impact that reduced SKP1 (and CUL1) expression has on CIN in non-transformed fallopian tube secretory epithelial cells, a cell of origin for high-grade serous ovarian cancer (Perets et al., 2013; Nakamura et al., 2018). This evidence concerns the gene CUL1 and cervical squamous intraepithelial neoplasia.