HOXC9, which acts as a regulator of cell proliferation and cycle related gene expression and as a mediator of RA action in neuroblastoma cells (Mao et al., 2011; Stoll et al., 2011; Wang et al., 2013), was the second most highly enriched motif in the right-biased DARs. The gene discussed is DARS1; the disease is neuroblastoma.