In melanoma, LAG3 can bind to MHC-IIs upregulated on tumor cells, upregulating MAPK/Erk and phosphatidylinositol-3-kinase (PI3K)/Akt pathways to confer melanoma cells resistance to Fas-mediated and drug-induced apoptosis (Hemon et al., 2011). This evidence concerns the gene FAS and melanoma.