Tumor cells additionally facilitate the development of MDSCs by secreting CCL2, CCL12, CXCL5 to attract IMCs into the TME while also secreting growth factors that recruit MDSCs in the bone marrow (Huang et al., 2007; Yang et al., 2008; Gabrilovich et al., 2012). The gene discussed is CXCL5; the disease is neoplasm.