Binding of TIGIT to CD155 (poliovirus receptor PVR) expressed on tumor cells results in the decreased secretion of pro-inflammatory cytokines such as IFN-γ, IL-17a, and TNF-α, and an increased secretion of the anti-inflammatory cytokine IL-10 (Figure 1B) (Zhang C. et al., 2020). This evidence concerns the gene IFNG and neoplasm.