CCN2 and pulmonary fibrosis: Ou et al. confirmed that simvastatin could reduce the number of neutrophils and lymphocytes, and inhibit the expression of TNF-α in the bronchoalveolar lavage fluid of mice, and it could also inhibit the expression of TGF-β and CTGF and reduce the accumulation of collagen in a murine model of bleomycin-induced pulmonary fibrosis [91].