It has been demonstrated that statins can inhibit the inflammatory response after lung tissue injury, reduce the number of inflammatory cells, decrease the expression of TGF-β/CTGF, inhibit the Rho signaling pathway and the phosphorylation of Smad2/3, suppress the activity of YAP/TAZ, and attenuate pulmonary fibrosis in basic science studies, including in vitro assays or animal models. Here, SMAD2 is linked to pulmonary fibrosis.