The sequence between intestinal injury, ghrelin secretion and GH release by the pituitary could be particularly relevant for solving ME/CFS given that “several of the main typical symptoms in severe ME/CFS, such as fatigue, myalgia, contractility, delaying muscle recovery and function, exertional malaise, neurocognitive dysfunction, and physical disability may be related to severe GH deficiency” (111). Here, GH1 is linked to Myalgia.