Thus, the iSAFE scores in the region were highest for the IBS, with the top-ranking variants corresponding to positions 8.3–8.6 Mb (iSAFE score≥0.09), near PRAG1 and Claudin 23 (CLDN23) coding genes and telomeric to MFHAS1 (Figure 3; Table 3). Here, CLDN23 is linked to irritable bowel syndrome.