As mentioned above, exercise induces dysglycemia in patients with T1DM, and many patients do not exercise for fear of hypoglycemia. Different approaches have been applied in the past to prevent or limit hypoglycemia, including increasing carbohydrate intake before exercise, reducing basal insulin, reducing bolus insulin for the meal before exercise, and interrupting basal insulin for patients on continuous subcutaneous insulin infusion (CSII) [24-26]. Athletes with T1DM should always check their blood glucose before exercise, looking for a target level of between 120 and 180 mg/dL [28]. This evidence concerns the gene INS and type 1 diabetes mellitus.