The UniProt (https://www.uniprot.org/) platform predicts that GPC2 has five hydrogen sulfur bond insertion sites, and it has been reported that the unique structure of GPC2 helps to bind to the Wnt signaling pathway, thus affecting the expression of MYCN Proto-Oncogene (MYCN) and regulating the proliferation of tumor cells (33). Here, GPC2 is linked to neoplasm.