In the subgroup analysis by etiological classification of liver cirrhosis, cirrhosis after HCV infection was positively associated with the risk of TNF-α-308G/A polymorphism (AA vs. GG: OR = 3.02, 95% CI: (1.15, 7.88), AA vs. GA + GG: OR = 2.68, 95% CI: (1.04, 6.95)). This evidence concerns the gene TNF and Cirrhosis.