To explore the treatment of recurrent gastric mantle cell lymphoma, Toby A. Eyre et al. [12] carried out relevant studies which proved the fast application of anti-CD19 CAR T-cell therapy in this field, the effectiveness of homologous stem cell transplantation, and the application of new therapies such as non-covalent and reversible BTK inhibitors, ROR1 antibody-drug conjugates and bispecific antibodies. The gene discussed is BTK; the disease is mantle cell lymphoma.