FN1 and familial pancreatic carcinoma: After Numb PRRL specific knockdown, the expression of E-cadherin was up-regulated, while the expression of N-cadherin, Vimentin, Fibronectin, Snail2 and ZEB1 were down-regulated (Fig. 4C), suggesting that Numb PRRL can promote EMT in pancreatic cancer cells.