For example, Chang et al. (2021) reported that high expression of DSG2 increased cancer cell invasiveness and led to worse prognosis in breast cancer, whilst the opposite was observed in another study, which found that knockdown of DSG2 in anaplastic thyroid cancer cells increased cell migration and distant metastasis in xenografts (Lee et al., 2020). The gene discussed is DSG2; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.