In anaplastic thyroid cancers, Lee demonstrated that DSG2 knockdown induced cell motility and invasiveness through the cMet/Src/Rac1 signaling axis and that targeting cMet inhibited DSG2 knockdown-induced distant metastasis in mouse xenografts (Lee et al., 2020). The gene discussed is RAC1; the disease is thyroid gland undifferentiated (anaplastic) carcinoma.