DSG2 and neoplasm: For instance, Han et al. (2018) reported that DSG2 expression was significantly higher in hepatocellular carcinoma tumor tissues than in matched noncancerous tissues and positively correlated with tumor size, tumor stage and unfavorable prognosis, while Xu et al. (2020) illustrated that the expression of DSG2 proteins was significantly lower in extrahepatic cholangiocarcinoma tissues than in normal tissues and that negative DSG2 expression was an independent poor prognosis factor.