When the genotype of AGTR1 TT and CYP2C9 ∗1/∗1 was used as the reference, the combined genotype of AGTR1 AC + CC and CYP2C9 ∗1/∗1 showed a higher rate of hypertension control with valsartan treatment in the unadjusted and adjusted statistical models (unadjusted: OR 2.953, 95% CI 1.267–6.880, P = 0.012; adjusted: OR 3.028, 95% CI 1.225–7.486, P = 0.016). This evidence concerns the gene CYP2C9 and Hypertension.