The present study aimed to investigate whether the antihypertensive effect of angiotensin receptor antagonist valsartan is associated with polymorphisms AGTR1 A1166C and CYP2C9∗3 in a Chinese population and provide information about the heterogeneity of antihypertensive drug responses, which would help the clinicians to make an informed decision about individualized medication for hypertension. The gene discussed is AGTR1; the disease is Hypertension.