CHI3L1 and Anxiety: Therefore, in the present study, we investigated whether N-Allyl-2-[(6-butyl-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidin-5-yl)sulfanyl]acetamide (G721-0282), an inhibitor of CHI3L1, could exert anti-anxiety effects through blockage of CHI3L1-mediated neuroinflammation.