Peripheral blood mononuclear cells can produce high concentrations of MIG, IP-10, IFN-γ, mRNA and higher proportion of CXCR3+ cells and in mononuclear cell regulation of lymphoid cells in atherosclerotic lesions, migration, and retention using CXCR3 antagonists NBI-74330 treatment in mice, by blocking CXCR3+ T cells from circular migration to atherosclerotic plaques, thereby reducing the formation of atherosclerosis; therefore, these findings suggest that T cell-driven inflammation may play an important role in the progression of human atherosclerosis. The gene discussed is IFNG; the disease is Atherosclerotic lesion.