The genetic alteration rates of other KLF family genes signature in CRC were (KLF1, 5%; KLF2, 6%; KLF3, 6%; KLF4, 5%; KLF5, 14%; KLF6, 7%; KLF7, 7%; KLF8, 7%; KLF9, 7%; KLF11, 5%; KLF12, 12%; KLF13, 6%; KLF15, 6%; KLF16, 6%; KLF17, 6%). The gene discussed is KLF2; the disease is colorectal carcinoma.