Adjusting for clinical factors (age, gender, T, N, and M stage), multivariate analysis (Figure 6) confirmed that high expressions of KLF3, KLF5, and KLF6 were independent risk factors for better OS in patients with CRC, while high expression of KLF15 was independent risk factor for poor OS in patients with CRC. The gene discussed is KLF5; the disease is colorectal carcinoma.