The elevated secretion of IL-1β and IL-18, and expression pattern of HMBOX1, NF-κB (cytoplasm), nuclear NF-κB, NLRP3, caspase-1, and GSDMD-N were all reversed by overexpression of HMBOX1 (Figures 5B–D), showing that sepsis-exos and miR-885-5p mimic had similar effects on AC16 cells. This evidence concerns the gene HMBOX1 and Sepsis.