The results showed that the mean methylation levels of AMH, C17orf82, HDAC9, IGFBP3, LRRC10B, PDE3A, PRDM6, SYT7 and TBX2 were significantly (Wilcoxon's two sample test) lower in ischemic stroke cases than in controls (Supplementary Figure 1). The gene discussed is LINC02875; the disease is ischemic stroke.