IGFBP3 and ischemic stroke: In the functional annotation clustering analysis, we found that ischemic stroke risk- and prognosis-associated genes (AMH, C17orf82, HDAC9, IGFBP3, PDE3A, PRDM6 and TBX2) were enriched in specific GO terms of biological process (Supplementary Table 7), including regulation of developmental process, muscle cell differentiation, muscle structure development, cell differentiation, cellular developmental process and regulation of muscle cell differentiation.