BF atrophy correlated with Aβ accumulation in amnestic MCI as well as AD (Fernández-Cabello et al., 2020, Kerbler et al., 2015, Teipel et al., 2014), and more recently, volume loss of the nucleus basalis of Meynert (NBM) was associated with tau pathology in individuals at risk for AD (Cantero et al., 2020). This evidence concerns the gene MAPT and Alzheimer disease.