Several pro-inflammatory (interleukin-2, interleukin-4, interleukin-8, interferon and tumor necrosis factor alpha) and anti-inflammatory (interleukin-10) cytokines are raised at presentation and can continue to remain elevated for several months thereafter, reflecting the inflammatory pathophysiology of takotsubo syndrome.43 Interestingly, interleukin-6 concentrations tend to be higher in patients with acute coronary syndrome, potentially reflecting the greater extent of myocardial necrosis.44 Here, IL6 is linked to Tako-tsubo cardiomyopathy.