Polymorphisms of the beta-1 and beta-2 adrenoreceptors genes have been associated with reduced left ventricular function in patients with takotsubo syndrome, but results are conflicting and inconclusive.22, 23 Larger studies are currently underway to explore potential genetic associations (GENETIC- NCT04513054). Here, ADRB2 is linked to Tako-tsubo cardiomyopathy.