Immunohistochemistry studies suggest that calcium-regulating proteins such as phospholamban, sarcoendoplasmic reticulum calcium-ATPase (SERCA) and sarcolipin are altered, resulting in depressed left ventricular contraction during acute takotsubo syndrome.80 Studies are currently underway that aim to assess myocardial calcium-handling in patients with takotsubo syndrome (MEMORY study, NCT04623788, Figure 6). This evidence concerns the gene PLN and Tako-tsubo cardiomyopathy.