119 genome‐wide significant DMRs associated with 118 unique genes 118 single CpG motifs (DMPs) associated with 107 unique genes: Some gene associated toasthma: ALOX15, CAPN14, HNMT, POSTNExtracellular matrix: COL16A1, COL5A2, COL5A3, ELN, HAS3, MMP14,Immunity: IFNGR2, HLKA‐DPA1, LAG3, NFIL3, PRF1, TNFSF13Cell adhesion CTNND1, EPPK1, GJA4epigenetic regulation ATXN7L1, H1F0, HIST1H1D, METTL1Airway obstruction GABRG3,Obesity C1QTNF1, GPC4Autophagy AMBRA1. The gene discussed is COL5A2; the disease is obesity due to melanocortin 4 receptor deficiency.