Differential DNAm were observed between non‐severe and severe.816 DMPs and 10 DMRs associated with asthma severity.16 pathways were significantly enriched among the 398 genes associated with these DMPs.59genes with multiple DMPS that is, LTB4R2, DPP10, IL17RA, CYFIP2, DNAH5, MRPL28, and PTPRN2, TMEM51, WDR25, HIPK3, and KLF1139 DMP levels associated with mRNA levels. The gene discussed is TMEM51; the disease is asthma.