utilized an advanced omics approach to identify an asthma regulatory locus, outside the linkage disequilibrium block of 17q12–21, which correlated specifically with the expression of ORMDL Sphingolipid Biosynthesis Regulator 3 (ORMDL3; located in 17q12–21), whose associated functions include sphingolipid homeostasis, myelination, ceramide metabolic process, neutrophil degranulation, and smooth muscle contraction. The gene discussed is ORMDL3; the disease is asthma.