In addition, they more frequently had previous history of anaphylaxis related to non‐COXi‐related triggers, other than Hymenoptera venom anaphylaxis (HVA), at the same time they more frequently showed angioedema and pruritus, together with signs of more advanced disease including higher sBT levels, together with a greater frequency of multilineage involvement of BM hematopoiesis by the KIT mutation, particularly among multiple reactors. Here, MT-CO1 is linked to angioedema.