Whether the KITD816V mutation has consequences on the activation threshold or the functionality of eosinophils and basophils in mastocytosis patients with mutilineage KIT mutation, and whether they are directly involved in DHRs to NSAIDs and other COXi, remains unknown and warrants further investigations, particularly among mastocytosis patients presenting with eosinophilia. The gene discussed is KIT; the disease is mastocytosis.