Multivariate analysis showed the following combination of variables to be independent predictors for multiple reactor hypersensitivity: female gender (odds ratio [OR]: 5.9, p = 0.009), multilineage involvement of BM cells by the KIT mutation (OR: 4.4, p = 0.02), past history of anaphylaxis caused by neither NSAIDs or other COXi nor Hymenoptera venom (OR: 5.0, p = 0.009), sBT ≥48 ng/ml (OR: 5.6, p = 0.005) and presence of flushing as a basal MC mediator release related symptom (OR: 4.2, p = 0.02). Here, KIT is linked to anaphylaxis.