IGHE and allergic disease: No significant differences were found among cases presenting with mucocutaneous manifestations versus anaphylaxis as regards the diagnostic subtype of mastocytosis, age at disease onset, duration of disease, gender, allergic sensitization, type of allergic disease, baseline manifestations, BMMC burden, total serum IgE levels, presence of diffuse osteosclerosis, absolute eosinophil blood count and type of tolerance.