Stimulated immune cells, like classically activated macrophages ‘M1,’ activated dendritic cells (DCs), IL‐33 and amphiregulin, innate lymphoid cells (ILC2), NK cells, Th1, follicular T helper cells (TFH), IFN‐Υ producing T CD8+ and B lymphocytes have inhibitory effects on tumourigenesis and tumour progression. The gene discussed is AREG; the disease is neoplasm.