PRKN and chronic obstructive pulmonary disease: This is in line with the literature, as CS-induced increases in PINK1 levels and decreased PRKN abundance have been described in several in vitro/vivo (airway) models (Ahmad et al., 2015; Ito et al., 2015; Kyung et al., 2018; Mizumura et al., 2014; Son et al., 2018; Wu et al., 2020) and in peripheral lung tissue and bronchial epithelial cells of (ex-smoking) COPD patients (Ahmad et al., 2015; Hoffmann et al., 2013; Ito et al., 2015; Mizumura et al., 2014).