Functional annotation clustering was performed to categorize the genes into classes like bacterial invasion of epithelial cells and ubiquitin-mediated proteolysis in E. histolytica-treated cells (Fig. S5A), mTOR signaling pathway, autophagy, endocytosis, pathogenic Escherichia coli infection, and tight junctions in Igl-treated cells (Fig. S5B). The gene discussed is MTOR; the disease is escherichia coli infection.