After the intervention (at day 180), the SAQ scores increased significantly, while the SAS and SDS scores and the serum levels of LDL-C and IL-6 decreased significantly in both Probio-M8 and placebo groups (P < 0.01 in all cases; Fig. 1B), suggesting that the intervention with atorvastatin and metoprolol both with and without adjunctive probiotics could effectively alleviate the clinical symptoms of CAD patients. This evidence concerns the gene IL6 and coronary artery disorder.