Dysregulation of TLR signaling leads to various infectious diseases or autoimmune disorders.[16] Consistent with the above observations that knockout of RNF115 promoted LPS‐induced production of proinflammatory cytokines in vivo, knockout of RNF115 resulted in resistance to the lethal infection of Salmonella typhimurium and S. typhimurium‐induced weight loss (Figure2A,B). Here, RNF115 is linked to autoimmune disease.