RNF115 and psoriasis: Imiquimod (IMQ) is a TLR7/8 agonist that exacerbates psoriasis in patients and induces psoriasis‐like lesions when topically applied to the shaved skin of mice.[36, 37, 38, 39] Intriguingly, the severity of skin inflammation was aggravated in Rnf115−/− mice compared to the Rnf115+/+ mice after IMQ treatment (Figure 2F,G).