The upregulation of miR-34 might partially reverse the tumor-suppressive effects of p53 within p53-deficient human pancreatic tumor cell lines through inhibiting the growth and invasion of clonogenic cells, inducing cell apoptosis and cell cycle arrest in G1 and G2/M phases, and sensitizing the cells to chemotherapy and radiotherapy.33 Coupled with these reported miRNAs, aconsequential number of deregulated miRNAs in pancreatic cancer,15–17 are thought to be involved in pancreatic cancer carcinoma. The gene discussed is TP53; the disease is pancreatic neoplasm.