TP53 and familial pancreatic carcinoma: The upregulation of miR-34 might partially reverse the tumor-suppressive effects of p53 within p53-deficient human pancreatic tumor cell lines through inhibiting the growth and invasion of clonogenic cells, inducing cell apoptosis and cell cycle arrest in G1 and G2/M phases, and sensitizing the cells to chemotherapy and radiotherapy.33 Coupled with these reported miRNAs, aconsequential number of deregulated miRNAs in pancreatic cancer,15–17 are thought to be involved in pancreatic cancer carcinoma.