In comparison with that within human pancreatic nestin expressing cells, hTERT-HPNE, the expression of miR-488 showed to be dramatically reduced within four pancreatic tumor cells, PANC-1, BxPC-3, MIA PaCa-2, and Capan-1, more downregulated in MIA PaCa-2 and PANC-1 cells (Figure1(g)). The gene discussed is NES; the disease is pancreatic neoplasm.