IFNG and tuberculosis: Furthermore, since increased IFN-γ productions may lead to over-reacted immune response and immunopathology and significant fractions of M. tuberculosis-infected individuals with active TB disease express quite appreciable amounts of IFN-γ, enhanced expression of IFN-γ driven by lncRNA-CGB may not mean full immune protection against M. tuberculosis infection.64 Thus, full investigations of more comprehensive lncRNAs-gut microbiota-immune network should be required for uncovering exact TB pathogenesis mechanisms.