PI3K/Akt/mTOR pathway is the most commonly activated signaling in human cancers and plays critical role in tumor cell survival, growth, angiogenesis, migration, and invasion, as well as metabolism regulation.[18] Through augmenting the activity of nutrient transporters and metabolic enzymes, PI3K/Akt pathway can reprogram cancer cellular metabolism to support the anabolic demands of aberrantly growing cells. This evidence concerns the gene AKT1 and neoplasm.