Since these two pathways are also involved in liver cancer initiation and progression, we screened through a cohort of candidates including signaling modulators SB431542, RepSox and LDN193189 (TGFβ and bone morphogenetic protein[BMP] signaling regulators); signaling and metabolic modulators CHIR99021 and BIO (GSK3β signaling and cell metabolism); epigenetic modulators valproic acid (VPA) and azacitidine (5‐AZA); and transcription modulator ATRA, which was also the differentiation inducer of APL cells. This evidence concerns the gene GSK3B and acute promyelocytic leukemia.