MMP2 and neoplasm: developed a supramolecular prodrug hydrogel for localized delivery of αPD1 and camptothecin (CPT, a chemotherapeutic) to synergistically boost the host's immunity against cancer (Figure 18).[156] They first synthesized an amphiphilic prodrug, diCPT‐PLGLAG‐iRGD, of which iRGD is peptide known to bind to Nrp‐1 and facilitate tumor interstitial penetration,[217] and PLGLAG is a peptide sensitive to MMP‐2.