In vitro and in vivo studies confirmed that αFc‐NPs immobilized with αPD‐L1 and αPD1 (imNAαPD1&αPD‐L1) could enhance T cell‐mediated cytotoxicity by simultaneously binding PD1 on T cells and PD‐L1 on tumor cells compared to physical mixing of αPD‐L1 and αPD1. Here, CD274 is linked to neoplasm.