FURIN and breast carcinoma: Apart from TLR agonist, hydroxychloroquine (HCQ), a known autophagy inhibitor, has recently been reported with the ability to induce the polarization of M2‐like TAM to M1‐like TAM.[183] Based on this, our group has recently developed a furin‐responsive aggregable NPs loaded with doxorubicin (DOX) and HCQ (AuNPs‐D&H‐R&C) for combination treatment against breast cancer.[184] After systemic administration, AuNPs‐D&H‐R&C could passively deliver to tumor site via EPR effect and formed aggregates under the triggering of overexpressed furin, leading to an increased size.