BAP is a positively charged and ROS‐responsive polymer used for binding and controlled release of TGF‐β siRNA, DSPE‐PCB is a polycation that enables endosome escape of siRNA and angiopep‐2 is dual‐targeting ligand used for crossing blood‐brain barrier and targeting glioblastoma cells. Here, TGFB1 is linked to glioblastoma.