In 2013, al‐Mashhadi et al.39generated proprotein convertase subtilisin/kexin type 9 (PCSK 9) mutation pigs, which exhibited reduced low‐density lipoprotein receptor (LDLR) levels and developed severe hypercholesterolemia and spontaneous atherosclerosis. The gene discussed is LDLR; the disease is familial hypercholesterolemia.