The rate of cholesterol elevation under a high‐fat diet in ApoE−/− pigs is higher than in the PCSK9 transgenic pigs and the LDLR−/− pigs, and the hypertriglyceridemia phenotype was found in ApoE−/− pigs but not the PCSK 9 transgenic pigs or the LDLR−/− pigs, suggesting that ApoE−/− pigs may be a better model to simulate human atherosclerosis. Here, APOE is linked to atherosclerosis.