Similarly, Zhang et al.35engineered pigs to carry three knock‐in risk genes, glucose‐dependent insulinotropic polypeptide receptor (GIPRdn), human islet amyloid polypeptide (hIAPP), and Patatin‐like phospholipase domain‐containing three variant rs738409 C>G p.I148M (PNPLA3I148M), resulting in glucose and lipid metabolism disorders, abnormal fat development and liver necrosis, ideal for research on non‐alcoholic fatty liver disease (NAFLD) and type II diabetes. This evidence concerns the gene IAPP and type 2 diabetes mellitus.