Based on the robust expression of TLR4 on many cell types in the liver, including Kupffer cells (KCs), hepatocytes and stellate cells,14 and the typical pro‐inflammatory role of TLR4/MD2 pathway,15, 16 it is generally believed that MD2 mediates inflammatory responses in NAFLD. This evidence concerns the gene LY96 and metabolic dysfunction-associated steatotic liver disease.