Of note, we detected LV‐GPR65 transduction in IBD CD4+ T cells showed higher expression of IL‐17A, RORC, IFN‐γ, TBET, and TNF‐γ compared with controls, whereas LV‐shGPR65 transduction in IBD CD4+ T cells leaded to an inverse effect showing a decrease of IL‐17A, RORC, IFN‐γ TBET, and TNF‐α expression (Figure 2B–F). This evidence concerns the gene IFNG and inflammatory bowel disease.