Importantly, we utilised both acute and chronic colitis models and observed that the lack of Gpr65 in CD4+ T cells could alleviate intestinal mucosal inflammation as evidenced by lowered weight loss, decreased DAI, less shortened colon, and decreased infiltration of IFN‐γ+, IL‐17A+ and TNF‐α+CD4+ T cells, suggesting that lack of Gpr65 in CD4+ T cells restrains intestinal mucosal inflammation. The gene discussed is CD4; the disease is Chronic colitis.