However, our results were different from the published data showing that more severe colitis was observed in Gpr65–/– mice induced by DSS and Citrobacter rodentium, characterised by the increase of proinflammatory mediators (e.g., Ifn‐γ, Tnf and iNOS) released by macrophages and lysosomal dysfunction of epithelial cells.22, 23. Here, GPR65 is linked to colitis.