In order to clarify the reason why GPR65 was increased in intestinal mucosal tissues of IBD patients, we collected intestinal mucosal tissues from 10 HC, 14 A‐CD and 12 A‐UC patients, and detected the expression of CD3, CD4, CD8, CD14, IL‐4, IFN‐γ, IL17A and GPR65 mRNA by qRT‐PCR, followed by a correlation analysis (Figure S2A‐H). This evidence concerns the gene CD4 and inflammatory bowel disease.