Improvement in gut health and muscle proteostasis in drosophila mediated by ↑ autophagy (Schinaman et al., 2019)↑ autophagy in human neuroblastoma cell lines (Lin et al., 2018)↓ SASP in a Nrf‐independent manner in senescent cells (Correia‐Melo et al., 2019; R. Wang et al., 2017)↓ IL1A and NFKB signaling thereby ↓ SASP via mTORC1‐dependent mechanism (Laberge et al., 2015)↓ adipose tissue inflammation (Paschoal et al., 2017). The gene discussed is NKRF; the disease is neuroblastoma.