The tumor microenvironment for both astrocytomas and oligodendrogliomas were similarly highly enriched for Iba1+ macrophage (astrocytoma: 198 Iba-1+ cells/10 HPF; oligodendroglioma: 274 Iba-1+ cells/10 HPF), but not CD3+ T or CD20+ B cells, both of which were found in smaller numbers when present within the TME [Figure 2B, D and F]. This evidence concerns the gene AIF1 and neoplasm.