SP2 and coronary artery disorder: In more detail, rs210962 (GWAS-derived) and rs7920217functional variants shared the potential to weaken the bindingof RE1 silencing transcription factor (REST) to the relatedgenomic loci (the DeFine scores of –0.0778 and –0.0888, respectively).rs2270574 and rs8106212 within the GWAS locifor CAD and platelet trait, respectively, shared the associationwith SP2 transcription factor, but had the opposite effects onTF binding according to DeFine scores (0.05020 to enhanceand –0.0973 to weaken the binding, respectively).