TGFB1 and neoplasm: Since CAFs secretecytokines involved in the recruitment and maturation ofmacrophages, T-lymphocytes and natural killer cells (IL-10,TGF-β, TNF, IFN-γ and IL-6), they increase the availabilityof the tumor to immune cells and promote antitumor immuneresponse (Marlow et al., 2008).