SLC5A2 and type 2 diabetes mellitus: At present, many studies have found that SGLT-2 inhibitors, including canagliflozin, empagliflozin, ertugliflozin, ipragliflozin, luseogliflozin, and tofogliflozin, can reduce weight in T2DM patients, playing an important role in the treatment of T2DM [12, 14–69].