A total of 20,019 patients with T2DM were enrolled in the present study, who were treated with SGLT-2 inhibitors, including canagliflozin, empagliflozin, ertugliflozin, ipragliflozin, luseogliflozin, and tofogliflozin, among which the dosages of canagliflozin, empagliflozin, ertugliflozin, ipragliflozin, luseogliflozin, and tofogliflozin were 100-300 mg/day, 10-25 mg/day, 5-15 mg/day, 50-100 mg/day, 2.5-5 mg/day, and 20-40 mg/day, respectively [12, 14–69]. This evidence concerns the gene SLC5A2 and type 2 diabetes mellitus.