For example, a mutation of TRPV3 or membrane‐bound transcription factor protease site 2 (MBTPS2) could lead to Olmsted syndrome, described by bilateral mutilating palmoplantar keratoderma (PPK) and periorificial keratotic plaques (Gatault et al., 2020). Here, MBTPS2 is linked to Palmoplantar keratoderma.