S100A16 and neoplasm: Furthermore, we also concluded that down-regulated of S100A6 (F = 3.52, P=0.0164; Figure 5(d)), S100A10 (F = 5.36, P=0.0015; Figure 5(h)), S100A16 (F = 6.69, P=0.00027; Figure 5(l)), and SDC1 (F = 4.02, P=0.00849; Figure 5(p)) were effectively related to lower tumor stage.