Mechanism studies showed that lncRNA GABPB1-AS1, as a competitive endogenous RNA, upregulated the expression of SP1 and promoted the Wnt/β-catenin pathway through sponge adsorption of miR-199a-3p, ultimately promoting the proliferation and malignant evolution of osteosarcoma. The gene discussed is GABPB1; the disease is osteosarcoma.