Research revealed that miR-424-5p negatively regulated ferroptosis by directly targeting ACSL4, an overexpressed ferroptosis-related protein, in ovarian cancer cells and that downregulation of miR-424-5p increased erastin- and RSL3-induced ferroptosis, resulting in inhibition of the progression of ovarian cancer 97. The gene discussed is ACSL4; the disease is ovarian carcinoma.