SIRT1 and Fanconi anemia: Resveratrol (3,5,4'-trihydroxystilbene), a plant polyphenol, has potential to activate Sirt1 expression and extend life span of simple organisms, including yeast and nematode 18, and rodent models 19, 20; Remarkably, Zhang et al. provides that evidence that Sirt1-mimetic drug resveratrol rescues hematopoietic deficits in Fancd2 KO mice, a typical murine model of Fanconi Anemia in humans 21.